Long-term monitoring of biomedical signals is essential for the modern clinical management of neurological conditions such as epilepsy. However, developing wearable systems, able to monitor, analyze, and detect epileptic seizures with long-lasting operation times, using current technologies is still an open challenge. Brain-inspired spiking neural networks (SNNs) represent a promising signal processing and computing framework as they can be deployed on ultra-low power neuromorphic computing systems, for this purpose. Here, we introduce a foundational SNN architecture, co-designed and validated on a mixed-signal neuromorphic chip, for always-on monitoring of epileptic activity. We demonstrate how the hardware implementation of this SNN captures the phenomenon of partial synchronization within neural activity during seizure periods. We benchmark the network using a full-custom asynchronous mixed-signal neuromorphic platform, processing analog signals in real-time from an Electroencephalographic (EEG) seizure dataset. The neuromorphic chip comprises an analog front-end (AFE) signal conditioning stage and an asynchronous delta modulation (ADM) circuit directly integrated on the same die, which can produce the stream of spikes as input to the SNN, directly from the EEG electrodes. A linear classifier in a post processing stage is sufficient to reliably classify and detect seizures, from the local features extracted by the SNN. This research marks a significant advancement toward developing embedded intelligent “wear and forget” units for resource-constrained environments. These units could autonomously detect and log relevant EEG events of interest in out-of-hospital environments, offering new possibilities for patient care and management of neurological disorders.